One of the best known paintings by an American
This is a short list. There are lots of sources.
Fun Stuff: (quite a bit here, this painting is often parodied)
http://www.americangothicparodies.com/ (a whole site devoted to parodies)
https://www.youtube.com/watch?v=6CgXHpT5bwk (how to create the painting)
1) Create your own parody. Pick a famous male / female pair.
2) Recreate the painting using a different setting.